The optimization of coumarin anticoagulant therapy: pharmacogenetics and computer assisted dose finding

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The optimization of coumarin anticoagulant therapy: pharmacogenetics and
computer assisted dose finding / Maarten Joseph Beinema. - [S.l. : s.n.], 2009
(Enschede : Gildeprint). - 171 p. : ill. ; 24 cm
Proefschrift Rijksuniversiteit Groningen. - Met lit. opg. - Met samenvatting in
het Nederlands.
ISBN 978-90-77113-97-4

Safety of drug therapy is one of the first concerns of physicians. Nevertheless, 5 to 10 percent of hospital admissions are estimated to be due to side effects from drug therapy. The effects of drugs are sometimes difficult to predict, and factors, such as drug-drug interactions and ageing, interfere with the safety of drug therapy. Monitoring of drug therapy is a toll that can improve drug safety. However, therapeutic drug monitoring is only useful in selected drugs.

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