Entrainment to daylength in the mouse circadian system : behavioural and molecular analyses

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This Ph.D. project originates from a large collaborative enterprise (BrainTime, funded by the European Fifth Framework program; QLRT-2001-01829). In this project, five research groups (PI's S. Daan, University Groningen; G.T.J. van der Horst, Erasmus University Rotterdam; U. Albrecht, University Fribourg; G. Eichele, Max Planck Institute of Experimental Endocrinology, Hannover; T. Roenneberg, University Munich) joined forces to perform molecular brain and behaviour studies to answer a series of questions on the mechanisms of entrainment by light and rhythm generation at the genetic, neural, and behavioural levels.
This thesis combines behavioural approaches, such as the determination of Phase Response Curves, with molecular techniques for studying old and new questions related to entrainment, using mice (Mus musculus) as a model. The 10 chapters are divided into to sections. The first section includes six chapters that deal with questions on the mechanism of entrainment by studying behavioural rhythms in mice. In the second section (four chapters) molecular techniques are applied to characterize the spatial and temporal patterns of gene expression in order to understand the basis of circadian entrainment at the molecular level.

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