Peroxisomal housekeeping processes and cell vitality

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Eukaryotic cells differ from prokaryotic ones in that they contain specific membrane bound compartments, the organelles. The advantage of this compartmentalization is obviously the creation of unique microenvironments with specific (bio)chemical properties, which increase the efficiency of certain cellular processes. Specialized functions of the cell can be handled with high efficiency by adaptation of these organelles to prevailing cellular needs. One of the important modes to achieve this is to precisely control the abundance and function of the organelles, a process termed organelle homeostasis. In addition, for optimal functioning, the quality of the organelles and their contents is continuously controlled and, when necessary, improved by repair or degradation of non-functional components. This process is termed organellar housekeeping.
The research detailed in this thesis deals with the identification and characterization of housekeeping processes related to peroxisomes.

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