DNA-based asymmetric catalysis

The goal of the research described in this thesis was to develop the general concept and methodology of DNA-based asymmetric catalysis, with the aim of using this concept to discover novel reactivities, and to develop mechanistic understanding of successful catalysts.

The main achievements reported in this thesis are:

i) The development of a highly enantioselective DNA-based catalyst for several important C–C bond forming reactions, i.e. the Diels-Alder, Michael, and Friedel-Crafts reaction.
ii) The first asymmetric syn-hydration of an α,β-unsaturated carbonyl compound, catalyzed by the first generation DNA-based catalysts.
iii) Insight into the reactivity and enantioselectivity of the highly enantioselective
second-generation catalysts.
iv) Insights into the structure of this catalyst.

	Titel en inhoud
	Hoofdstuk 1
	Hoofdstuk 2
	Hoofdstuk 3
	Hoofdstuk 4
	Hoofdstuk 5
	Hoofdstuk 6
	Hoofdstuk 7
	Hoofdstuk 8
	Samenvatting
	Dankwoord
	Complete dissertatie

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