The role of sex steroid hormones in Purkinje cell death in the staggerer mutant during aging and development

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The comprehension of neuronal degeneration during aging has become one of the major objectives in Neuroscience during the last decades. This thesis will focus on both endocrine and neural senescence since they overlap during the aging process and are mechanistically intertwined.
This thesis is divided into two main themes involving the staggerer mutant (Rorα sg/sg), a natural mutant of RORα (Retinoid acid receptor-related Orphan Receptor α) nuclear recemptor: I) the relationship, in vivo, between (neuro)endocrine aging, degenerative disorders and genetic make-up in the cerebellum II) characteristics of the development of the Rorα sg/sg cerebellum and of its synaptic architecture ex vivo.

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