Anti-adhesive properties and physiological stability of surface-grafted polyacrylamide brush coatings

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Biomedical implants based on synthetic polymers are being used more and more in medicine for applications such as joint replacement, vascular grafts, contact lenses and voice prostheses. Silicone rubber (SR) is an example of a non-biodegradable synthetic polymer that is very suitable for biomedical applications because of its good chemical, physical and physiological properties. Unfortunately, silicone rubber has two major drawbacks: (1) the presence of siloxane oligomers and/or catalyst residues that can easily diffuse out of the SR material and give rise to inflammatory reactions and (2) protein adsorption to the SR surface, leading to the formation of a harmful biofilm. In this thesis these two issues are investigated.

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