Defining and determining the properties of the human sleep homeostat

To summarize, the principal findings upon which this thesis is built, are these:
1. The most accurate measure of the human chronotype on the 24-h scale relative to external time is the timepoint at a point in the 30–40% range of habitual sleep length on free days.
2. The free-day mid-sleep time correlates negatively with the gain constant from Achermann’s elaboration of the two-process model. Age is a confounding factor in this relationship, which itself is positively associated with the gain constant.
3. The gain constant describes the gradual dissipation of Process S while allowing for the inherently irregular course of SWA.
4. A new parameter (Process Z) is introduced to describe the local cortical differentiation of the kinetics of SWA homeostasis as distinct from the more global, integrative Process S involved in the timing of sleep onset and end.
5. Rather than conventional delta range (0.75–4.5Hz), 2–3Hz is the frequency range in which SWA homeostasis is clearest.
6. Frontal, use-dependent cortical areas are involved in SWA regulation the most, while occipital SWA exhibits slightly different characteristics. SWA response may not be immediate to current demand in these areas.

	Title and contents
	Chapter 1
	Chapter 2
	Chapter 3
	Chapter 4
	Chapter 5
	Chapter 6
	Chapter 7
	Summary
	Samenvatting
	Acknowledgements
	Bibliography
	Complete thesis

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