Molecular basis of two novel dehalogenating activities in bacteria : structure/function relationships in an evolutionary context

It is generally believed that evolution is at the heart of species differentiation of all living organisms, a hypothesis that was first stated by Charles Darwin in his revolutionary work "The origin of Species". Although this hypothesis was originally based on phenotypic similarities between different species, the current knowledge of the genomes of various species shows that interspecies relationships are even more evident on the genetic level, even when species have very dissimilar phenotypes. Central to the current view of Dawinian evolution and species differentiation are: (i) mutation/recombination of the genetic code and the corresponding phenotypic changes (mutation); (ii) differential survival of altered individuals in the population (selection); and (iii) the propagation of beneficial changes in the population by (a)sexual replication (amplification). ....

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