Cerebral neurotrophins and behavioral aspects of a neurodevelopmental model of schizophrenia

Damage during prenatal development of certain brain regions of the limbic system as the entorhinal cortex and hippocampus are possibly involved in the development of psychiatric disorders associated with stress, anxiety and impairments in sociality and learning and memory abilities as schizophrenia. Because neurotrophins, particularly both NGF and BDNF, play a crucial role in brain neurogenesis, control some aspects of brain disorders and participate in the regulation of the fine tuning of behavior and cognition we used a rat model of entorhinal cortex and hippocampus maldevelopment to study neurotrophins and behavior. ...

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