Secretion stress in Bacillus subtilis.

The Gram-positive eubacterium Bacillus subtilis is capable of secreting large amounts of proteins into its growth medium. As at least some heterologous proteins are efficiently secreted by B. subtilis, this bacterium is a potentially useful cell factory for the production of valuable proteins, such as enzymes or biopharmaceuticals. In this context, it is important to employ healthy cells that secrete large amounts of high quality proteins. When the cell is sick, its energy is
primarily spent for its survival and the protein production ill suffer. If the quality of the secreted protein is not optimal, the secreted protein may, firstly, not be active
and, thus, useless for many applications. Secondly, malfolded proteins are readily degraded, which result in reduced yields of these proteins.

Zie: Abstract.

Abstract

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