Catabolite inactivation of maltose transport proteins in saccharomyces cerevisiae

Plasma membrane proteins form the entrance to the cell for nutrients and signal from the environment. S.cerevisiae preferably uses some nutrients, like glucose, where as other compounds in the medium may be toxic to the cells. lt is therefore crucial for a cell to regulate the activity of its plasma membrane proteins in response to nutrient availability and cellular needs. Regulation of protein activity can be achieved at the gene level by controlling transcription and/or mRNA stability. This only provides long-term control as many proteins are relatively long-lived (>10 hours) and the activity of these proteins persists long after gene transcription has been shut off. The cell thus also needs to regulate protein activity at the level of the catalysts themselves, that is by modification and/or degradation of the protein. ...

Zie: Summary and concluding remarks

Zie: Summary and concluding remarks

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