Targeting of captopril to the kidney: towards selective renal ACE inhibition

The present thesis deals with the targeting of the angiotensin converting enzyme (ACE) inhibiting drug captopril to the kidney. Drug targeting is a technique that aims at a more specific action of drugs by restricting their distribution to a specific part of the body. In other words, the targeting of drugs can increase the availability of a drug at a site in the body where the action is desired, while, at the same time, the concentrations of the drug is decreased at other sites in the body. As a consequence of the altered body distribution, drug targeting can improve the therapeutic profile of a drug by elevating drug concentrations selectively at specific sites in the body.

	Title and contents
	Chapter 1
	Chapter 2
	Chapter 3
	Chapter 4
	Chapter 5
	Chapter 6
	Chapter 7
	General discussion and perspectives
	Summary
	Samenvatting
	Publications
	Dankwoord
	Complete thesis

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