Approaches to drug resistance in solid tumors : with emphasis on lung cancer

De novo or acquired resistance of tumor cells to anticancer agents remains a major problem for the therapeutic efficacy of chemotherapeutic drugs. Most solid tumors are intrinsically insensitive or acquire resistance after initial response to chemotherapy. Different mechanisms seem to play a role in drug resistance such as the overexpression of membrane efflux pumps, a decrease in the activity of target enzymes, and an increase in cellular detoxifying and DNA repair capacity. ...

Zie: Summary

	Title and contents
	Chapter 1
	Chapter 2
	Chapter 3
	Chapter 4
	Chapter 5
	Chapter 6
	Chapter 7
	Chapter 8
	Summary, conclusions and future directions
	Samenvatting, conclusies en vooruitblik
	List of abbreviations
	Dankwoord
	Stellingen
	Comlplete thesis

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