Acetylcholine release in the hippocampus : a study of septo-hippocampal neurons in freely moving rats

This thesis describes the development of a method for studying acetylcholine release from septo-hippocampal neurons in the rat. Two dialysis probes were implanted in each rat, one in the hippocampus and one in the medial septum. Both probes were used for measuring acetylcholine, as well as for the administration of drugs. All the experiments had dual objectives. On one hand, to identify the major factors that control the release of acetylcholine, and on the other hand, to evaluate and explore the possibilities of this experimental design. We anticipated that the design would provide unique information on the regulation of acetylcholine release in alive and unstrained animals

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Summary

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