Melatonin on-line : development of trans pineal microdialysis and its application in pharmacological and chronobiological studies

At certain times, magic remedies become popular that are supposed to cure almost all diseases. Recently melatonin has become known in this respect. An important trigger for this increased interest was a book with the suggestive title 'The melatonin miracle', written by the researchers Pierpaoli and Regelson. Without any trace of reserve, claims are made on effectiveness in cardiovascular diseases, depressions, insomnia, cancer, immune deficiency etc. Very appealing are the suggested rejuvenation and the increase in life-span by up to 25%. Unfortunately, such popular writings change the image of a new and promising research field to a kind of alternative medicine and invoke a certain contempt by some people.
The research that is presented in this thesis is directed towards the regulation of melatonin production, also in relation to the suprachiasmatic nucleus, and the use of melatonin measurements in the development of melatonin-like compounds to clinically useful drugs. An extremely important part of the research was the development of a new technique, which enabled the measurement of melatonin production in freely moving animals, mainly rats.

Zie: Summary.

	title and contents
	chapter 1
	chapter 2
	chapter 3
	chapter 4
	chapter 5
	chapter 6
	chapter 7
	chapter 8
	chapter 9
	chapter 10
	references
	samenvatting
	summary

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