Mechanisms underlying structural plasmid instability in bacillus subtilis.

The use of plasmids as cloning and expression vehicles in a variety of prokaryotes has been instrumental in our fundamental understanding of bacterial genetics, as well as in the development of new biotechnological applications. Plasmid biology has been studied extensively over the past decades, both in Gram-positive and Gram-negative bacteria. Research on plasmid replication and maintenance has received considerable attention in the Gram-positive soil-bacterium B. subtilis. Because of its non-pathogenic nature and very high protein secretion capacity, this organism is of great value for industrial applications. Besides E. coli, B. subtilis has been well characterized, both genetically and physiologically, and well-established transformation- and cloning systems are available....

Zie: Summary and general discussion

Summary and general discussion

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