Biomolecular and pharmacokinetic studies on drug delivery preparations with dual activity on HIV-1

the work described in this thesis focuses on the features of negatively charged human serum albumins (NCAs) with the aim to produce intrinsic active drug carriers for anti-HIV-1 therapy. The NCAs, earlier developed in our laboratory, are proteins in which extra negative charges are introduced by modification of the e-NH2 groups of the lysines either by succinylation or aconitylation. This results in the prototypes Suc-HSA and Aco-HSA, modified proteins that displayed a high potency against HIV-1 replication with IC50 values in the low nanomolar range. ...

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Summary

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