Chemometric analysis of aged RP-HPLC stationary phases

This thesis describes how optimal mobile phases on aged columns can be found. For this purpose, the aged columns are categorized in columns that show no changes, columns that show only hydrophobicity changes and columns that show also selectivity changes in retention. The quality of columns during routine use can be assessed with respect to these categories with the use of techniques borrowed from statistical quality control in combination with Principal Component Analysis (PCA) and three-way analysis. ...

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Summary

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