A Field-oriented postmarketing surveillance study on the teratogen acitretin

The primary aim of this thesis was to collect information and to provide new evidence for monitoring and counsellinig of women of childbearing age who have been or are exposed to acitretin. The studies in the present thesis were all initiated after the alert on the teratogenic dermatological agent acitretin in October 1990, when it was notified that unexpectedly, the lipophilic compound etretinate was found in plasma of acitretin users. This resulted in an extension of the recommended post-therapy contraception period from 2 months to 2 years, which inevitably had a large impact on acitretin exposed women of childbearing age. ...

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Summary

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