Clinical relevance of porphyrin determinations in porphyria.

This thesis deals with hereditaryd iseasesin the synthesiso f heme. Heme presents a prosthetic group in a number of important proteins, like hemoglobin, cytochromes and the cytochrome P450 oxidases. In chapter 1 the heme synthesis and its regulation are described. Intermediary products in the synthesis of heme are 8-aminolevulinic acid, porphobilinogen, and series of compounds called porphyrinogens and porphyrins.

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Summary

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