Dissertaties - Rijksuniversiteit Groningen
 
vp.jpg
English | Nederlands

New methods for the enantiomeric excess determination using NMR

(1994) Hulst , Anthony Jacques Ronald Lambert

The synthesis of enantiomerically pure compounds is an important objective of the organic chemistry. Especially in the field of medicine and pesticides, mostly one enantiomer is responsible for the biological activity. Certain examples are known where the other enantiomer is more than isomerical balast, and its presence gives rise to side-effects. It is not surprising that the regulatory authorities in Europe and the United States usually impose that chiral compounds are marketed as single enantiomers. Growing interest and improvement in enantioselective synthesis leads to an increased demand for accurate, reliable and convenient methods of measuring the enantiomeric composition. A large number of methods for the determination of the enantiomeric excess (e.e.) of regardless which chiral substrate have been developed over the years. A popular, accurate, and moreover, fast method for the determination of the enantiomeric composition is to make use of NMR techniques (Nuclear Magnetic Resonance). This thesis describes the research carried out towards the development of new methods for enantiorneric excess determination of amino acids and not naturally occuring α-alkylated amino acids by means of NMR techniques.




file:Title and contents
file:Chapter 1
file:Chapter 2
file:Chapter 3
file:Chapter 4
file:Chapter 5
file:Chapter 6
file:Chapter 7
file:Samenvatting
file:Summary
file:Complete thesis

Gebruik a.u.b. deze link om te verwijzen naar dit document:
http://irs.ub.rug.nl/ppn/312843003

Meer informatie in de catalogus
Meer informatie in Picarta

[print]Afdrukken op bestelling.



ID 31230
Moeder ID 28107
Volgorde hulst.a.j.r.l
Naam a.j.r.l.hulst
Publiceren yes
OAI-naam Dissertation
Path faculties/science/1994/a.j.r.l.hulst/
Naam Cover vp.jpg
Gemodificeerd op: 2013-02-15 14:28:01
Digitaal ID 487f18f94afbf
Instelling Faculty of Mathematics and Natural Sciences
Datum beschikbaarstelling 1994-02-18
Titel New methods for the enantiomeric excess determination using NMR
Titelvolgorde New methods for the enantiomeric excess determination using NMR
Elektronisch yes
Ruilverkeer mogelijk no
Printen in opdracht yes
Exporteer? yes
Aantal pagina's 213
Publicatiejaar 1994
Verslagjaar 2008
Taal en_US
Type Dissertation
Samenvatting EN The synthesis of enantiomerically pure compounds is an important objective of the organic chemistry. Especially in the field of medicine and pesticides, mostly one enantiomer is responsible for the biological activity. Certain examples are known where the other enantiomer is more than isomerical balast, and its presence gives rise to side-effects. It is not surprising that the regulatory authorities in Europe and the United States usually impose that chiral compounds are marketed as single enantiomers. Growing interest and improvement in enantioselective synthesis leads to an increased demand for accurate, reliable and convenient methods of measuring the enantiomeric composition. A large number of methods for the determination of the enantiomeric excess (e.e.) of regardless which chiral substrate have been developed over the years. A popular, accurate, and moreover, fast method for the determination of the enantiomeric composition is to make use of NMR techniques (Nuclear Magnetic Resonance). This thesis describes the research carried out towards the development of new methods for enantiorneric excess determination of amino acids and not naturally occuring α-alkylated amino acids by means of NMR techniques.
Uitgever University of Groningen
Rechten University of Groningen
PPN 312843003
Trefwoord GOO Enantiomeren; Analytische chemie; NMR; Proefschriften (vorm);
Trefwoord NBC 35.39 analytische chemie: overige;
Auteur Hulst , Anthony Jacques Ronald Lambert;
Naamsvariant auteur(s) Hulst, Ron;
Promotors Feringa, B.L.; Vries, N.K. de;


 
To top