A study on programmed drug release from tablets

This thesis shows the extension of the applicability of the megaloporous system for drugs
with different physico-chemical properties, like solubility and pK.. Procaine HC1, a highly soluble drug, can successfully be formulated in the programmed release megaloporous system, by using Carnauba wax, stearyl alcohol and carboxyvinyl polymer to constitute the restraining matrix granules. Megaloporous systems with salts of weakly basic drugs, like ketanserin tartrate and mianserin hydrochloride, show the achievement of almost pH-independent release profiles by incorporation of a proper acidic excipient in the programmed release system.

	Title and contents
	Chapter 1
	Chapter 2
	Chapter 3
	Chapter 4
	Chapter 5
	Chapter 6
	Chapter 7
	Chapter 8
	Chapter 9
	Chapter 10
	Samenvatting
	Publications
	Dankwoord
	Complete thesis

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