Construction and analysis of mixture-process variables designs as applied to tablet formulations

This thesis is concerned with methods for the systematic optimization of pharmacutical formulations. Such methods are of interest for pharmaceutical industries. In order to limit the problem only one kind of formulation is examined. This is the direct compressed tablet. Several techniques which can be used for the optimization of a direct compressed tablet are described. This kind of tablet is made by mixing the ingredients (among which the pharmacon) for some time, addition of a lubricant and again mixing. From the resulting powder fixed portions are taken which are compressed in a die. ...

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