Dopaminergic and serotonergic agents : synthesis and pharmacological evaluation of 2-aminotetralins and related tricyclic compounds

The main interest of our research group is the medicinal chemisq of agonists
and antagonists of the neurotransmitters dopamine (DA) and serotonine (5-HT) and
their modes of pharmacological interaction with dopaminergic and serotonergic
neurotransmitter systems in the brain. The group is currently interested in the rational
design, synthesis and pharmacological evaluation of new dopaminergic and serotonergic
agents with clinical potential.
Dopamine is an important neurotransmitter in the brain and is known to play an
important role in Parkinson's disease, schizophrenia, and possibly depression.
Serotonine is thought to be involved in various functions such as anxiety, aggression,
depression, stress, sexual behaviour, and body temperature.

	Title and contents
	Chapter 1
	Chapter 2
	Chapter 3
	Chapter 4
	Chapter 5
	Chapter 6
	Chapter 7
	Chapter 8
	Chapter 9
	Chapter 10
	Summary
	Samenvatting
	List of publications
	Dankwoord
	Complete thesis

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