Heterologous gene expression in lactococcus lactis.

Lactic acid bacteria are of major economic importance, as they occupy a key position in the manufucture of fermented foods. Fermentation serves the preservation of the foods and, moreover, adds to the development of flavour and texture of the products. A considerable amount of research is currently being devoted to the development of lactic acid bacterial strains with improved characteristics, that may be used to make fermentations pass of more efficiently, or to make new applications possible. Therefore, and because the lactococci are designated 'GRAS' organisms (generally regarded as safe) which may be used for safe production of foreign proteins, detailed knowledge of homologous and heterologous gene expression in these organisms is desired. Expression of heterologous genes may add to both improvement of fermentation qualities and the extension of the applicability of the lactococci. ...

Zie: Summary and general discussion

Summary and general discussion

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