Conformational study of cinchona and ephedra alkaloids

Chirality and Natun an closely associated. Living organisms use chiral catalysts
(enzymes) to synthesize many of their chemical constituents. Over millions of
years the complex compositions of enzymes have developed into efficient and
specific catalysts for the synthesis (and breakdown) of chiral organic compounds.
Because of the complexity of mynatic reactha, it is difficult to study the details
of their reaction mechanisms directly from experiments. Recently several
breakthroughs in the design and the synthesis of organic catalysts have taken
place. With these catalysts it is possible to control the stereoselectivity of some
reactions with efficiencies rivalling those of enzymes. In many casts th-e chiral
organic catalysts am, like cnzymea, natclral products or their derivatives. However,
such catalysts are much smaller than enzymes and are thus better suited to
mechanistic studies. A recent example is given by lnouel . With the dipeptide
cyclo-phcnyldaninc-histidinea s chiral caEatyst in a reaction between beaualdehyde

	Title and contents
	Chapter 1
	Chapter 2
	Chapter 3
	Chapter 4
	Chapter 5
	Chapter 6
	Summary
	Samenvatting
	Complete thesis

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