Evaluation of tumor therapy by pet : use of 11C-amino acids and 18FDG

Aspects of metabolic activities of tumors, such as glycolysis and synthesis of macromolecules, can be discriminated from activities of the tissues they originated from. These altered metabolic states may conveniently be investigated and quantified with positron emission tomography (PET) by the use of radiopharmaceuticals labelled with short-lived positron-emitting radionuclides, such as glucose analogs and amino acids. PET offers ample possibilities to measure the effect of treatment on tumors in terms of induced changes of metabolic activities. These changes can possibly be used as indicators of the therapeutic effects on tumors. The aim of this thesis is to contribute to the knowledge on the applicability of PET for the clinical evaluation of tumor treatment. Before PET can be applied in patients for monitoring therapy-induced changes on tumor growth, studies with tumor-bearing animals are necessary.

	Title and contents
	Chapter 1
	Chapter 2
	Chapter 3
	Chapter 4
	Chapter 5
	Chapter 6
	Chapter 7
	Samenvatting
	Nawoord
	Complete thesis

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