Purification and characterization of the 5-HT reuptake system from human blood platelets.

This thesis is focussed on the characterization and subsequent isolation of the 5HT-reuptake system. The 5HT-reuptake system provides for the translocation of released serotonin into the presynaptic neuron. This transport is regulated by the imipramine binding site (IBS), inasmuch as binding to this regulatory site strongly impedes the reuptake of serotonin. Evidence has been accumulated that this regulatory site and the actual carrier constitute distinct, mutually exclusive, subsites on the same transport system rather than that they are identical to each other. ...

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