Synthetic models for the active site of alcohol dehydrogenase.

In this thesis the synthesis of Zn2+ and Co2+ complexes with sulfur and nitrogen containing ligands as model compounds for the active site of Horse Liver Alcohol Dehydrogenase (HLADH) is described. HLADH is an enzyme which reversibly oxidizes alcohols to aldehydes or ketones, making use of the coenzyme NAD+/NADH. The active site of HLADH contains a
zinc ion, coordinated by two cysteines, a histidine and a water molecule (or hydroxide ion). This zinc ion is necessary for the catalytic activity of the enzyme. ...

Zie: Summary

Summary

Meer informatie in de catalogus
Meer informatie in Picarta