Critical evaluation of the determination of bioavailability by numerical deconvolution.

In the Introduction the principal methods for the assessment of the extent and rate of bioavailability are reviewed, and their limitations and drawbacks are shortly discussed. Since a direct numerical deconvolution technique with staircase approximation seemed to meet the requisites of the 'ideal method' rather well, this method was chosen as a starting point for the development and validation of an appropriate method for the determination of drug input.

In Chapter I the theoretical basis of the application of linear time-invariant systems is presented. The interpretation of the term 'drug input' depends on the route of administration of the reference dose, also referred to as unit dose impulse input. The term 'drug input' may be defined as the appearance of unchanged drug in the general circulation (definition of bioavailability) in the case where the unit dose impulse input is an intravenous bolus administration. ...

Zie: Summary.

Summary

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