Improving the measurement of skin autofluorescence, or: working on the clinical applicability of skin autofluorescence from a biomedical engineering perspective

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The detection of an increased risk of cardiovascular diseases is important in preventive health care. The measurement of autofluorescence (AF) of the skin with an AGE reader is a non-invasive and fast method for the assessment of advanced glycation end products (AGEs). AGEs are metabolic products that accumulate in tissues with low collagen turn-over, such as skin. Their amount is an independent predictor of cardiovascular risk. Many measurements of skin were performed in healthy subjects to assess age-dependent reference values in a Caucasian population. A new calculation method was developed for skin AF measures in people with dark skin. The method of AGE-measurement was also reliable in patients who are using haemodialysis.

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