Early effects of brain death on kidney injury and outcome after transplantation

In the last decades, kidney transplantation has become the treatment of choice for end-stage renal failure. The main source for donor organs in kidney transplantation has traditionally been heart-beating brain dead patients (donation after brain death, DBD). Due to the persistent shortage of donor organs, however, living (un)related donors and, to a lesser extent, kidneys from non-heart-beating donors have been increasingly accepted for transplantation. Transplantation with well-matched living donor-recipient combinations was known to have superior results compared to those with DBD and NHB donor kidneys. During the past fifteen years it became obvious that fully mismatched living-unrelated grafts also have better survival outcomes than kidneys retrieved from DBD donors with a very reasonable match for HLA antigens. This difference in results cannot be fully attributed to prolonged cold ischemia times in grafts procured from DBD donors, since no significant effect of cold ischemia time on kidney transplantation outcome was seen with preservation times up to 24 hr. Thus, other risk factors must be responsible and should explain the difference in success rates between living and cadaveric kidney transplantation. ...

Zie: Chapter 9

	Titel en inhoud
	Hoofdstuk 1
	Hoofdstuk 2
	Hoofdstuk 3
	Hoofdstuk 4
	Hoofdstuk 4
	Hoofdstuk 6
	Hoofdstuk 7
	Hoofdstuk 8
	Hoofdstuk 9
	Nederlandse samenvatting
	Dankwoord
	Volledige dissertatie

Meer informatie in de catalogus
Meer informatie in Picarta

Afdrukken op bestelling.