Individual approach towards optimal oral anticoagulation

In a variety of diseases, the use of antithrombotic agents and thrombolytic therapy for
primary and secondary prevention of both arterial and venous thromboembolism
have significantly influenced morbidity and mortality. This thesis addresses the use of
vitamin K antagonists (VKA) in five of these diseases, i.e. deep vein thrombosis,
pulmonary embolism, atrial fibrillation, heart valve replacement and coronary artery
disease. The focus lies on the ability to achieve an optimal level of anticoagulation, in
which arterial or venous thromboembolic events are prevented, without an unacceptable risk for major bleeding. Furthermore, in patients with coronary artery disease undergoing coronary-artery-bypass-grafting surgery, the choice of aspirin over vitamin K antagonists is re-evaluated.

	Titel en inhoudsopgave
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	Samenvatting, discussie en toekomstperspectieven
	Samenvatting
	Dankwoord
	Volledige dissertatie

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