Effects of environmental exposures on asthma phenotypes in the mouse : contributing and protecting mechanisms

The scope of this thesis was to investigate the mechanisms via which different factors induce aggravation of, or provide protection against asthma. Throughout this thesis a house dust mite (HDM)-induced mouse model for allergic asthma has been used. The following parameters were investigated to characterize allergic asthma:
* HDM-specific IgE in serum
* Eosinophilic inflammation in lung tissue
* Presence of high levels of the TH2 cytokines IL-4, IL-5 and IL-13 in lung tissue
* Methacholine (MCh) responsiveness

Zie: Chapter 8

	Titel en inhoud
	Hoofdstuk 1
	Hoofdstuk 2
	Hoofdstuk 3
	Hoofdstuk 4
	Hoofdstuk 5
	Hoofdstuk 6
	Hoofdstuk 7
	Hoofdstuk 8
	Samenvatting in het Nederlands
	Dankwoord
	Compleet proefschrift

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