Exploring predictors of chemotherapy efficacy and toxicity in testicular cancer

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Testicular cancer, the most common malignancy in young men aged 15-35 years, has high cure rates. Treatment of disseminated testicular cancer with platinum-based chemotherapy - the current standard regimen consists of bleomycin, etoposide and cisplatin (BEP) - has led to a considerable increase in cure rates. With current survival rates exceeding 90%, the group of long-term testicular cancer survivors is growing. Life expectancy and quality of life of testicular cancer survivors are threatened by treatmentrelated side effects. Cardiovascular disease is an important cause of increased morbidity and mortality during both chemotherapy and long-term follow-up. Direct chemotherapyinduced vascular toxicity as well as development of an unfavourable cardiovascular risk profile may contribute to the increased risk for cardiovascular disease. Individual-tailored treatment, leading to further improvement of survival and reduction of treatment-related toxlc~tyi.s the current challenge. Aim of this thesis is to explore predictors of chemotherapy efticacy and chemotherapyre atea toxicity, in particular vascular toxicity, in testicular cancer patients treated with platrnum-based chemotherapy.

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