Pathogenetic mechanisms in Parkinson's disease : studies with positron emission tomography

In this thesis, PET is used to study the role of blood-brain barrier (BBB) dysfunction and neuroinflammation as possible contributory factors in the pathogenesis of Parkinson's disease (PD). The first part of the thesis focuses on the involvement of BBB P-glycoprotein transporter (P-gp) function in PD pathogenesis using ["C]-verapamil PET. Protective function of the BBB may be an important factor linking neurotoxic substances to the development and progression of neurodegenerative diseases. The second part of this thesis focuses on the role of neuroinflammation in the progression of PD. The use of [11C]-PKI1195 as a tracer for neuroinflammation was investigated in an animal PD model as well as in PD patients. Furthermore, the effect of anti-inflammatory treatment with a selective cyclo-oxygenase-2 inhibitor was studied in vivo with PET.

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