Thrombotic complications in liver transplantation

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The coagulopathy of patients with end-stage liver disease requiring orthotopic liver transplantation (OLT) is complex and often unpredictable. Despite clear evidence of an increased bleeding tendency in patients with cirrhosis, many circumstances also promote hypercoagulation. The consequences of hypercoagulability include the morbidity and mortality of thrombotic and thromboembolic events. The aim of this dissertation was to gain more insight into the incidence and development of thrombotic and thromboembolic events in OLT and to analyze t he possible influence of the antifibrinolytic drug aprotinin on this.

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