Dissertaties - Rijksuniversiteit Groningen
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Targeted immunotherapy for ovarian cancer

(2009) Leffers, Ninke

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Ovarian cancer is generally treated with cytoreductive surgery followed by chemotherapy. As prognosis depends heavily on the amount of residual disease after primary debulking surgery, involvement of experienced gynaecological oncologists in the the treatment of ovarian cancer patients improves survival. Furthermore, with the introduction of taxanes in the mid-nineties, survival of (in)completely debulked advanced stage patients has improved. Despite these developments in treatment, ovarian cancer remains the most lethal gynaecological malignancy. To improve prognosis, new therapeutic modalities are currently being explored. This thesis focuses on the immunotherapy as a therapeutic option for ovarian cancer. Results of a clinical immunotherapy trial and translational research supporting this modality as well as highlighting potential pitfalls are presented.

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