Bone marrow-derived cells in renal repair

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The kidney can recover after acute renal injury due to its highly effective endogenous regenerative capacity. However, under certain conditions the balance between injury and repair can get disturbed. This can ultimately lead to chronic renal failure, which is an increasing problem in the clinical setting. Therapy for renal failure has greatly improved over the years, especially by the introduction of kidney transplantation. Nevertheless, due to the shortage of donor organs and the relatively low long-term success rate after kidney transplantation, new therapeutic strategies are highly desirable. Bone marrow-derived cells (BMDC) might offer a therapeutic solution for renal failure. In this thesis we explored the differentiation choices of BMDC after acute renal injury.

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