Radiolabelled interleukin 2 for in vivo imaging of activated T-lymphocytes

The progress of our understanding and knowledge of the pathophysiology of chronic inflammatory diseases has prompted the development of several new specific receptor-binding peptide radiopharmaceuticals. Data obtained so far on the clinical use of radiolabelled peptides have demonstrated that this approach is safe and effective in vivo for the study of selected cell populations in several inflammatory conditions.
It is now possible to assess the activity of the disease, but also to verify its ultimate effects: cell killing.
New “tailored peptides” are being continuously tested in vivo to match new diagnostic challenges and for therapy decision making and follow-up. It is hoped that by using new molecular approaches, including the development of new tools for high resolution imaging, we will increasingly contribute to the clinical management of patients with inflammatory diseases. In particular radiolabelled-IL2 is a unique example of how these techniques can be revolutionary in the management of patients. Activeted T-cells are constantly present, although in a low percentage, in circulating blood, primary and secondary lymphoid tissues, including oral and gut mucosa. But what is the treshold for pathology? When does a localized increase of activated Tcells requires to be treated, what is the best treatment and how should we follow-up the efficacy of such a treatment? Now that we have the possibility to image in-vivo and non-invasively the tissue distribution of activated T-cells, all these questions require an answer.
Our understanding of human pathology and molecular biology has evolved the clinic of human diseases from the symptomatological classification of the 19th century to a physiopathological classification of disease of the 20th century. The 21st century is giving rise to a biomolecular classification of diseases, also aided both by new tools for high-resolution imaging and by the development of radiolabelled peptides to diagnose and manage inflammatory conditions.

	Title and contents
	Chapter 1
	Chapter 2
	Chapter 3
	Chapter 4
	Chapter 5
	Chapter 6
	Chapter 7
	Chapter 8
	Summary
	Samenvatting
	Curriculum vitae
	Acknowledgements
	Complete thesis

Meer informatie in de catalogus
Meer informatie in Picarta

Afdrukken op bestelling.