Skin autofluorescence and advanced glycation endproducts

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Advanced glycation endproducts (AGEs) are biomarkers of metabolic stress and are thought to contribute to the increase of long-term complications in chronic age-related diseases, such as diabetes and renal failure. Until recently, all AGE-assays needed invasive sampling. However, tissue autofluorescenceis related to the accumulation of AGEs. Therefore we developed a noninvasive Autofluorescence Reader (AFR), to measure skin GE accumulation noninvasively. The aims of this thesis were to validate the AFR as a measure of AGE accumulation, to evaluate skin autofluorescence as a clinical tool and its relationship with long-term complications in diabetes and renal failure.

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