Dissertaties - Rijksuniversiteit Groningen
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Aspects of endothelial function testing in coronary vascular disease

(2003) Monnink, Stefan Hugo Jozef

The endothelium plays a key role in onset and progression of coronary vascular disease, endothelial dysfunction has indicated prospectively to be related with the occurrence of new coronary vascular events, and there is support that dysfunction is not irreversible. Intracoronary acetylcholine testing can only be justified if it is a safe test, with prognostic significance in large cohort studies, without an alternative such as forearm measurements.
This thesis describes the aspects of endothelial function testing in coronary vascular disease by discussing the following statements:
a. Evaluation of different methods to measure coronary endothelial function in patients with angina pectoris: pre and contra
b. Aspects of acetylcholine-induced coronary endothelial function testing in clinical practice: different patients have different outcome
c. Treatment of endothelial dysfunction with ACE-inhibitors: a pre-clinical setting The different methods of statement a. are described in section II, clinical practice is shown in section III, and experimental ACE-inhibitor therapy in section IV.

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