Design and development of a miniaturised flow-through measuring device for the in vivo monitoring of glucose and lactate

The aim of this thesis was to develop a (portable) miniaturized device for long-term
continuous real time in vivo monitoring of analytes, such as glucose and lactate. Both glucose and lactate are markers for energy metabolism, as glucose is the major energy substrate for the body and lactate is released during oxygen deficiency. Glucose and lactate can be monitored in a wide variety of settings, such as during athletic performance and pathological situations like brain trauma, diabetes and heart failure. Because an interruption in the energy supply to organs, such as the brain and the heart, can quickly lead to lifethreatening situations, the need and potential of these devices have been long recognized in clinical diagnostics. By means of real time continuous in vivo monitoring rapid clinical intervention can be established and, as a consequence, may prevent further damage.
Additionally, for large patient groups, such as patients suffering from diabetes mellitus, the quality of life will be improved when frequent finger pricking to control their blood glucose level can be significantly reduced.

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	dankwoord.pdf
	list_of_publications.pdf
	samenvat.pdf
	thesis.pdf

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