Neurohormonal activation, angiogenesis, and heart failure. Clinical and experimental studies

The aim of the studies was to investigate: 1) whether changes in microvasculature, angiogenesis, and angiogenesis factors occur in heart failure, and affect its outcome and 2) whether neurohormonal correlates can be identified that modulate these factors, and 3) wheter correction of the microvascular abnormalities with specific neurohormonal inhibitors is possible. It was shown that changes in microvasculature, angiogenesis, and angiogenesis factors occur in heart failure, although it is not established yet whether changes in microvasculature, angiogenesis, and angiogenesis factors affect the outcome of heart failure. The second aim yielded data on the impact of neurohormonal parameters, and signaling proteins that confer neurohormonal activation. We established that blockade of the AT, receptor, beta-receptor and ERK may be involved in microvascular abnormalities....

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