The spleen as essential organ in the immune respons to encapsulated bacteria

Immune responses to pneumococcal polpaccharides (PPS) derived from the capsule of
Strqtw.s show a completely different response pattern compared to protein antigens.
Ig}vI * well as IgG antibodies are rapidly induced but also decline quite fast [1-6]. The nature of
the induced memory is still a m).ctery as secondary ftoost) vaccination does not lead to increased
antibodylevels[ 6], but clinicalp rotectiond oess eemt o be obtainedU ;7;8].O assicalI gG switched
memory cells are not induced but longeviry of antibodies is thought to compensate for these cells
[9J. The splenic marginal zone has been shown to play a vital role in the rapid response against
polpaccharide antigens [10-14]. Children below the age of 2 years and patients receiving
chemotherapys how a reduceda nti-polpaccharider esponseT. he explanationf or this most lilaiy
is due to a non-functional marginal zone.

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