Expression and regulation of ABC transporter genes during liver regeneration

One may assume that cells that proliferate during severe liver damage require well-developed defense mechanisms to withstand cellular damage under conditions of severe metabolic stress.
One potential mechanism of cellular protection is the expression of efflux pumps, belonging to the ABC superfamily of membrane transporters, which are able to dispose toxic metabolites from cells.
The aim of the work described in this thesis was to characterize the expression of ABC transporter genes in different hepatic cell types after experimental or disease-related liver damage in animal and humans.

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	chapter 5
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	dankwoord
	list of publications
	samenvatting
	stellingen
	summary and general discussion
	thesis

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