Intimal hyperplasia, the obstacle in bypass grafts

The purpose of this thesis was to design new strategies to improve the patency of small diameter bypass grafts in the arte-rial circulation by reducing the formation of intimal hyperplasia. The following goals were formulated to evaluate the ef-ficacy of these new strategies:
1. To inventory the factors responsible for, and the strategies designed to control the formation of intimal hyperplasia in vein grafts in the arterial circulation.
2. To introduce a model to quantify early platelet and leucocyte deposition onto synthetic bypass grafts in vitro.
3. To evaluate the effect of periadventitial application of a sulfated carbohydrate polymer on the formation of intimal hy-perplasia in autologous vein graft in rab-bits.
4. To evaluate the effect of superhydro-phobic modification of small diameter ex-panded polytetrafluoroethy-lene vascular graft on platelet deposition and on the for-mation of intimal hyperplasia both in vivo and in vitro.
5. To evaluate the gastroepiploic artery as autologous bypass graft for peripheral by-pass grafting in pigs.

	titlepages/contents
	chapter 1
	chapter 2
	chapter 3
	chapter 4
	chapter 5
	chapter 6
	chapter 7
	samenvatting voor niet ingewijde
	summary
	thesis

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