Management of pemphigus

We describe a case of transition from pemphigus vulgaris into pemphigus foliaceus accompanied by distinct shift in anti-desmoglein antibody profile as detected by ELISA. The patient presented with painful oral erosions, later followed by flaccid blisters and erosions on the skin. A diagnosis of pemphigus vulgaris was made based on the typical clinical presentation and histopathology, immunofluorescence, and ELISA studies. Successful therapy consisted of daily prednisolone up to 60 mg, adjuvant dexamethasone pulse therapy and azathioprine. After a period of eight months in complete remission the patient presented again with a new solitary erythematous lesion on the scalp with crusted scales. Histology showed clefting of the granular layer with acantholysis. Apparently the pemphigus vulgaris had transformed into pemphigus foliaceus. This shift from PV to PF was accompanied by the disappearance of anti-desmoglein 3 (dsg3) antibodies and the re-occurrence of anti-desmoglein 1 (dsg1) antibodies as detected by ELISA.

	titlepages/contents
	chapter 1
	chapter 2
	chapter 3
	chapter 4
	chapter 5
	chapter 6
	chapter 7
	dankwoord
	samenvatting
	stellingen
	summary
	thesis

Meer informatie in de catalogus
Meer informatie in Picarta

Afdrukken op bestelling.