Apoptosis and autoantibodies in systemic lupus erythematosus

The general objective of the studies in this thesis is to elucidate the role apoptotic cells play in the etiopathogenesis of SLE. First, we focus on the function of soluble Fas (sFas), a molecule which has been described to interfere with the induction of Fas-mediated apoptosis. It has been suggested that elevated levels of sFas hamper apoptosis (autoreactive) lymphocytes, subsequently resulting in autoimmunity.

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	chapter 1
	chapter 2
	chapter 3
	chapter 4
	chapter 5
	chapter 6
	chapter 7
	chapter 8
	chapter 9
	chapter 10
	chapter 11
	chapter 12
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