Assessment of change in clinical evaluation

The main theme of this thesis deals with methodological problems in the assessment of treatmentrelated change in health-related functional status (HRFS). There is a large number of factors that potentially affect the interpretation of change in HRFS by the researcher and the perception of the direction and magnitude of change by patients who have undergone a particular medical intervention. Change over time in HRFS measures was assessed in patients with severe spinal spasticity and in patients whose symptoms were considered to belong to what is labelled ‘heart failure’.
Both groups underwent a treatment with known efficacy in order to detect treatment-related change.

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	dankwoord
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	samenvatting
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	thesis

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